![]() ![]() The aim of this study was to determine the effects of iaTA in the mouse destabilisation of the medial meniscus (DMM) model, to determine its predictive utility by comparing with well-described effect size and known factors that modify efficacy in patients. ![]() ![]() Intra-articular triamcinolone-acetate (iaTA) is a well established therapy for short-medium-term relief of knee OA symptoms. There has been limited research directed towards evaluating how the effect size in a relevant pre-clinical OA model corresponds to the minimal clinically important difference (MCID) for a drug beneficial in human OA. The reasons for this lack of 'translation' are complex and involve issues both with the design and conduct of human clinical trials, and how well the pre-clinical animal models predict outcomes in people. Get and manage your themes, visual styles, icons, wallpapers, mouse cursors, etc. Yet OA continues to be one of the major causes of chronic pain and disability with no effective disease- or symptom-modifying therapies developed. It includes 41 freeware products like Scanning Utility 2000 and Canon MG3200 series MP Drivers as well as commercial software like Canon Drivers Update Utility (39.95) and. In the case of a disease like osteoarthritis (OA) with multiple phenotypes, a plethora of animal models have been developed to study disease mechanisms, identify biological targets and test potential therapeutics. Purpose: In the current paradigm of biomedical research, pre-clinical animal models form the foundation of the translational drug-discovery pathway. ![]()
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